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For over two decades, clinical studies have extensively explored the therapeutic effects of ketamine for treating unipolar depression and major depressive disorder. These studies consistently emphasize ketamine’s robust and rapid antidepressant effects. They demonstrate a significant reduction in depression severity within hours post-infusion, with effects lasting weeks, and often even longer.
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Research on ketamine’s efficacy in bipolar disorder has primarily focused on treatment-resistant cases and adjunctive therapy, such as oral antidepressants and mood stabilizers. Like depression, findings suggest a rapid onset of antidepressant effect, with onset as early as four hours, but with conflicting results regarding duration.
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Ketamine therapy is a treatment approach that utilizes the potential psychiatric benefits of ketamine in a controlled and supervised environment. Ketamine blocks NMDA receptors while also releasing Brain-Derived Neurotrophic Factor (BDNF), a protein that promotes the growth of neurons. BDNF is thought to play a role in neuroplasticity, a mechanism that can reduce the effects of depression.
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